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BoNT Kinetics

Experimental data concerning the onset of paralysis of skeletal muscles induced by BoNT/A at the isolated rat neuromuscular junction (NMJ) and in other systems from several laboratories were simulated with two different kinetics minimalist models: 3-Step Model and 4-Step Model (Lebeda, Adler, Erickson, & Chushak (2008). Requires PDF Reader. Download PDF).

3-Step Model 4-Step Model
Analytic Expressions a graphical representation of 3-step model analytic expressions a graphical representation of 3-step model analytic expressions
Model Simulations image of 3 Step Model image of 4 step model


Note:

Model simulations require Java Web Start. If you do not have it installed in your system, you may download it from Sun Microsystems, Inc.. If you encounter any problem in launching these models, please contact us at botdb[AT]mail.nih.gov.





Last updated in September 2010



Sponsored by U. S. Army Medical Research Institute of Infectious Diseases (USAMRIID) in collaboration with the National Cancer Institute (NCI) and Advanced Biomedical Computing Center (ABCC).Support for this project was provided by the Defense Threat Reduction Agency Joint Science and Technology Office-Chemical Biological defense (DTRA JSTO-CBD) project 3.10043_07_RD_B and by the National Cancer Institute, National Institutes of Health, under contract No. HHSN261200800001E. a logo of the U.S. Army Medical Research Institute of Infectious Disease a logo of the National Cancer Institute, United States a logo of the Advanced Biomedical Computing Center, Advanced Technology Program
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