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Kinetics Minimalist Model - Parameters

Rate Description Value Units Reference PMID Species Conditions Temp (°C) pH Comments
kB receptor binding rate 0.058 min-1 Simpson, 1980 6243359 mouse in vitro NMJ 35-36 ~7.2  
kT translocation rate 0.141 min-1 Simpson, 1980 6243359 mouse in vitro NMJ 35-36 ~7.2  
kL lytic (toxic) rate 0.013 min-1 Simpson, 1980 6243359 mouse in vitro NMJ 35-36 ~7.2  
kS bulk solution to receptor rate ≥0.01 min-1 Lebeda et al., 2008   mouse in vitro NMJ 35-36 ~7.2 Simpson, 1980 (PMID: 6243359)
kS bulk solution to receptor rate 0.001 min-1 Lebeda et al., 2008 18551355 mouse in vivo i.m. injection     raw data from
Aoki, 2002 (PMID: 12076646)
and Keller, 2006 (PMID: 16490322)
kS bulk solution to receptor rate 0.00015 min-1 Lebeda et al., 2008 18551355 human in vivo i.m. injection     raw data from
Dressler and Adib Saberi, 2005 (PMID: 15650306)
kON association rate of BoNT/A
to its binding sites
0.0138 nM-1 min-1 Dolly et al., 1982 7043781 mouse brain synaptosomes 4    
kOFF dissociation rate of BoNT/A
from its binding sites
0.0072 min-1 Dolly et al., 1982 7043781 mouse brain synaptosomes 4    
kON association rate of BoNT/A
to its binding sites
0.056 nM-1 min-1 Lebeda et al., 2008 18551355 mouse brain synaptosomes 35    
kOFF dissociation rate of BoNT/A
from its binding sites
0.029 min-1 Lebeda et al., 2008 18551355 mouse brain synaptosomes 35