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Sequence Graphical Query

The three main proteins involved to form neurotransmitter SNARE (Soluble NSF Attachment REceptor) complexes are synaptobrevin (also known as VAMP (Vesicle-Associated Membrane Proteins), SNAP-25 (synaptosomal-associated protein of 25 kDa), and syntaxin.

To view the sequences of these proteins and other proteins such as light chain, heavy chain, hemagglutinin (HA-17, HA-33, and HA-70) involved in the mechanism of action of botulinum neurotoxin, click on a corresponding region inside the image below.


a diagram depicting Mechanism of Action of Botulinum Toxin Click here to view synaptobrevin (VAMP) sequences Click here to view  SNAP-25 sequences Click here to view  syntaxin sequences Click here to view  light chain sequences Click here to view  heavy chain sequences Click here to view  HA-17 sequences Click here to view  HA-33 sequences Click here to view  HA-70 sequences


Mechanism of Action of Botulinum Toxin
Reference: Arnon et al., J.Amer. Med. Assoc. 285:1059,2001

Last updated on June 10 2008


Sponsored by U. S. Army Medical Research Institute of Infectious Diseases (USAMRIID) in collaboration with the National Cancer Institute (NCI) and Advanced Biomedical Computing Center (ABCC).Support for this project was provided by the Defense Threat Reduction Agency Joint Science and Technology Office-Chemical Biological defense (DTRA JSTO-CBD) project 3.10043_07_RD_B and by the National Cancer Institute, National Institutes of Health, under contract No. HHSN261200800001E. a logo of the U.S. Army Medical Research Institute of Infectious Disease a logo of the National Cancer Institute, United States a logo of the Advanced Biomedical Computing Center, Advanced Technology Program
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